Agression gene identified
Monday, August 21st, 2006Ever wonder why some people are always so agressive and so hard to get along? well… researchers have recently identified an agression gene in Fruit Flys Drosophila melanogastar (not so fruity after all huh?). See below:

Researchers Herman Dierick and Ralph
Greenspan of The Neurosciences Institute in San Diego, California, set
out to see if they could breed high levels of belligerence back into
lab strains and to learn what genes might be implicated. They designed
a cage in which 11 small containers of fly food were evenly spaced to
serve as distinct "territories" for the insects. 120 Males+ 60 females were introduced to this environment. Only the
males deemed most aggressive–as judged by behaviors such as charging,
lunging, holding, and tussling–were removed and mated (score!).
After 20
generations, the aggressive insects scored more than 30(!) times higher
than the controls did on a "fighting index" that measured how
ferociously they fought, Dierick and Greenspan report. To see what genes might be involved in
this increased aggression, the team used microarrays to look for
differences in gene expression in fly brains. Several dozen genes were
expressed differently in the superaggressive flies, compared to
controls, but flies with mutations in one gene called Cyp6a20
were especially combative. This gene encodes one of a group of enzymes,
called cytochrome P450s, which are involved in a number of biological
processes including development, reproduction, and detection of
pheromones.
Source: Dierick and Greenspan Nature Genetics, August 13, 2006. Also see Trudy MacKay in a similar study from PLOS Genetics on August 2nd, 2006


