Archive for August, 2006

Agression gene identified

Monday, August 21st, 2006

Ever wonder why some people are always so agressive and so hard to get along? well… researchers have recently identified an agression gene in Fruit Flys Drosophila melanogastar (not so fruity after all huh?). See below:

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Researchers Herman Dierick and Ralph
Greenspan of The Neurosciences Institute in San Diego, California, set
out to see if they could breed high levels of belligerence back into
lab strains and to learn what genes might be implicated. They designed
a cage in which 11 small containers of fly food were evenly spaced to
serve as distinct "territories" for the insects.  120 Males+ 60 females were introduced to this environment.  Only the
males deemed most aggressive–as judged by behaviors such as charging,
lunging, holding, and tussling–were removed and mated (score!).

After 20
generations, the aggressive insects scored more than 30(!) times higher
than the controls did on a "fighting index" that measured how
ferociously they fought, Dierick and Greenspan report. To see what genes might be involved in
this increased aggression, the team used microarrays to look for
differences in gene expression in fly brains. Several dozen genes were
expressed differently in the superaggressive flies, compared to
controls, but flies with mutations in one gene called Cyp6a20
were especially combative. This gene encodes one of a group of enzymes,
called cytochrome P450s, which are involved in a number of biological
processes including development, reproduction, and detection of
pheromones.

Source: Dierick and Greenspan Nature Genetics, August 13, 2006.  Also see Trudy MacKay in a similar study from PLOS Genetics on August 2nd, 2006

Humanity defined~

Wednesday, August 16th, 2006

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To what extend are we different from primates? what makes us human and others just animals, albeit sharing 96% of our genome?  Prof. David Haussler, a revolutionary thinker, a computer scientist, and now a self-taught geneticist used aligned sequences from many animals and compared with human sequences.  He was able to identify regions with large number of changes within humans but virtually none in all other species, which are closedly related with humans, and he indicated these human lineage-specific changes. 

In particular, he discovered an RNA-gene that is highly expressed with reelin, a regulator of brain (cortical) development.  This gene is expressed in a type of cells called Cajal-Retzius cells of the subpial granular layer, a layer thought to contain the Cajal-Retzius neurons and their precursors migrating tangentially from the outside the neocortex (unique in human).  It is also present in the upper cortical plate, presumably representing the cells that are finishing up their radial migration.

source: Pollard et al, Nature 2006 (august 16th) doi:10.1038/nature05113, advanced publication online.

The Obama Bill

Thursday, August 10th, 2006
A new bill was introduced by IL senator Barack Obama to create a new agency that oversees molecular diagnostics and targeted therapeutics…
I think there are too many unreliable genetic home grown tests… even HerbalLife is making a genetic testing kit…

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NEW YORK (GenomeWeb News) - A US Senator
last week introduced the first significant piece of legislation
addressing pharmacogenomics that if approved into law could have broad
implications for the development of molecular diagnostics and targeted
therapeutics.

 

 

 

Introduced by Illinois Senator
Barack Obama last Thursday, the bill, entitled the “Genomics and
Personalized Medicine Act of 2006,” would create a new federal agency
to oversee personalized medicine.

 

 

 

The
agency would regulate the rate and scale of genomics research
and physician education. Itb would also regulate incentives for
developing genomic diagnostics and drugs, regulating genetic tests
under the Clinical Laboratories Improvement Act, and overseeing genomic
privacy and direct-to-consumer advertising.

 

 

 

It would also create a tax credit for developers of certain companion diagnostic tests.

 

 

 

The
bill contains provisions for $10 million to regulate the quality of
genetic tests, including creating a genetic testing specialty under
CLIA; and $30 million to regulate advertising for DTC genetic tests.
The bill also encourages legislation of genetic privacy and
non-discrimination.

 

 

 

“The entire bill itself
will help expand pharmacogenomics,” Jennifer Leib, Affymetrix’
associate director for government relations and public policy, told GenomeWeb News sister publication Pharmacogenomics
Reporter
this week.

 

 

 

Ed
Abrahams, executive director of the Personalized Medicine Coalition,
said the bill “raises the profile of personalized medicine, underlining
the fact that this paradigm requires new guidelines for regulation,
reimbursement, privacy, and other concerns.”